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KMID : 0378019740170050595
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New Medical Journal
1974 Volume.17 No. 5 p.595 ~ p.608
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A Study on Hemodilution Extracorporeal Circulation
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Abstract
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Some physiological changes including complete blood count, plasma hemoglobin, electrolytes with calcium and magnesium, and acid base balance were investigated on hemodilution extracorporeal circulation.
As pump-oxygenator Sigmamotor pumps and Rygg-Kyvsgaard bubble type oxygenator were utilized with high flow rate in eighteen acyanotic and fifteen cyanotic cases.
The following results were obtained.
(1) Significant decrease of hemoglobin and hematocrit was noted after bypass through operation and in the postanesthesia room, but white blood cell count showed no significant deviation from the control value.
Free plasma hemoglobin value showed marked increase after cardiopulmonary bypass.
(2) Serum sodium and potassium values showed no definite changes during and after extracorporeal circulation and in the immediate postoperative period, though chloride decreased significantly during bypass and returned to the control value at the end of operation in acyanotic group.
(3) Serum calcium remained at the normal value during and after total body perfusion and no significant deviation from the control value was noted.
(4) Serum magnesium decreased significantly during perfusion but increased to the control value after bypass.
(5) Acid base balance study showed the following results. In acyanotic group result before perfusion
showed pH of 7.35, at the beginning of perfusion 7.45, after. 30 minutes of perfusion 7.43 with partially compensated respiratory alkalosis, immediately after pump-off 7.36, and 30 minutes after pump-off 7.32 with uncompensated metabolic acidosis.
In cyanotic group result before perfusion showed pH 7.26 with uncompensated metabolic acidosis, at the beginning of perfusion 7.47 with partially compensated respiratory alkalosis, after minutes of perfusion 7. 46 with compensated respiratory alkalosis, immediately after pump-off 7.35, nd 30 minutes after pump-off 7.34 with uncompensated metabolic acidosis.
In both groups compensated respiratory alkalosis developed during perfusion and 30 minutes after pump-off uncompensated metabolic acidosis are noted.
Department of Thoracic Surgery, College of Medicine, Seoul National University
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